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type="text/css"></style> <div id="ct" class="ct2 wp cl"> <div class="mn"> <div class="bm_haa cl"> <div class="bm_h cl"> <a href="http://www.oecr.com/portal.php?mod=rss&catid=62" class="y xi2 rss" target="_blank" title="RSS">订阅</a><h1 class="xs2">文章</h1> </div></div> <div class="kjkjb"> <div class="bm vw" style="margin-bottom:0;"> <div class="h hm"> <div class="zxtoux"><img src="http://www.oecr.com/uc_server/avatar.php?uid=54876&size=small" /></div> <h1 class="ph">无线激活的植入物使用光来治疗膀胱问题 </h1> <p class="xg1"> 时间：2019-1-7 08:40<a class="zz" href="home.php?mod=space&uid=54876">作者：update</a> 阅读<em id="_viewnum">(570)</em> 评论: <a href="http://www.oecr.com/portal.php?mod=comment&id=7356&idtype=aid" title="查看全部评论"><em id="_commentnum">5</em></a></p> <div class="zxfb" ><a href="http://www.oecr.com/portal.php?mod=rss&catid=62" class="y xi2 rss" target="_blank" title="RSS">订阅</a></div> </div> <!--[diy=diysummarytop]--><div id="diysummarytop" class="area"></div><!--[/diy]--> <div class="s"> <div class="ss"><div><span>导读： </span>目前，如果人们患有诸如尿失禁或膀胱过度活动症等泌尿问题，需要药物或电子神经刺激植入物。然而，实验性新植入物可以更好地工作，使用集成微LED来解决该问题。</div> </div> <!--[diy=diysummarybottom]--><div id="diysummarybottom" class="area"></div><!--[/diy]--> <div class="d"> <!--[diy=diycontenttop]--><div id="diycontenttop" class="area"></div><!--[/diy]--> <table cellpadding="0" cellspacing="0" class="vwtb"><tr><td id="article_content"><div> 目前，如果人们患有诸如尿失禁或膀胱过度活动症等泌尿问题，需要药物或<a href="http://electronic.oecr.com" target="_blank" class="relatedlink">电子</a>神经刺激植入物。然而，实验性新植入物可以更好地工作，使用集成微LED来解决该问题。</div><div><br></div><div><p style="text-align: center;"><a href="data/attachment/portal/201901/07/084006xytidya8yatok9xx.jpg" target="_blank"><img src="data/attachment/portal/201901/07/084006xytidya8yatok9xx.jpg"></a></p></div><div><br></div><div> 目前使用的植入物通过向控制器官的神经传递电流来调节膀胱功能。然而不幸的是，这些装置有时会破坏向其他器官的正常神经信号，导致脱靶效应。药物治疗同样可能导致其自身的不良副作用。</div><div><br></div><div> 考虑到这些局限性，华盛顿大学圣路易斯医学院，伊利诺伊大学和西北大学的科学家们开发出了原型软体植入物。在实验室大鼠实验中，通过“小手术程序”植入无电池装置，在动物的膀胱周围像弹力带一样包裹。</div><div><br></div><div> 研究人员还将称为视蛋白的蛋白质注入器官。这些蛋白质由一种与膀胱神经细胞结合的病毒携带，使它们对光信号变得敏感。随着大鼠的膀胱随后充满尿液然后排空，植入物检测到器官的相关扩张和松弛。这些数据通过蓝牙传输到外部手持阅读器设备 - 它利用算法确定膀胱何时真正充满并且合法地需要清空，以及何时过于频繁地清空。在后一种情况下，读者自动提示植入物激活其LED，照亮神经细胞。这降低了这些细胞的活性，恢复了正常的膀胱功能。</div><div><br></div><div> 研究人员现在计划制造更大的植入物用于其他动物试验，着眼于最终开发出一种用于人类的模型。据认为，结合相同技术的植入物也可用于身体的其他部位，用于治疗慢性疼痛，或刺激胰腺根据需要分泌胰岛素。</div><div><br></div><div> 然而，在此之前，需要进行更多的研究。“我们还不知道我们是否可以使用病毒方法实现视蛋白的稳定表达，更重要的是，这是否可以长期安全，”华盛顿大学的Robert W. Gereau教授说道。关于这项研究的论文的作者。“这个问题需要在临床前模型和早期临床试验中进行<a href="http://opticaltest.oecr.com" target="_blank" class="relatedlink">测试</a>，以确保策略完全安全。”</div><div><br></div><div> 该论文最近发表在《自然》杂志上。</div><div><br></div><div><br></div><div><p microsoft="" yahei",="" simsun;="" background-color:="" rgb(255,="" 255,="" 255);="" text-align:="" center;"="" 255);"="" style="text-align: center; word-wrap: normal; margin: 0px; padding: 0px; color: rgb(143, 143, 143); font-family: Tahoma, "Microsoft Yahei", Simsun; background-color: rgb(255, 255, 255);"><b microsoft="" yahei",="" simsun;="" word-wrap:="" normal;"="" style="word-wrap: normal;"><font size="5" color="#f00000" style="word-wrap: normal;">欢迎关注光研科技服务号</font></b></p><p microsoft="" yahei",="" simsun;="" background-color:="" rgb(255,="" 255,="" 255);="" text-align:="" center;"="" 255);"="" style="word-wrap: normal; margin: 0px; padding: 0px; color: rgb(143, 143, 143); font-family: Tahoma, "Microsoft Yahei", Simsun; background-color: rgb(255, 255, 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