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type="text/css"></style> <div id="ct" class="ct2 wp cl"> <div class="mn"> <div class="bm_haa cl"> <div class="bm_h cl"> <a href="http://www.oecr.com/portal.php?mod=rss&catid=58" class="y xi2 rss" target="_blank" title="RSS">订阅</a><h1 class="xs2">文章</h1> </div></div> <div class="kjkjb"> <div class="bm vw" style="margin-bottom:0;"> <div class="h hm"> <div class="zxtoux"><img src="http://www.oecr.com/uc_server/avatar.php?uid=54876&size=small" /></div> <h1 class="ph">突破性研究解释免疫系统如何使癌细胞进入休眠状态 </h1> <p class="xg1"> 时间：2019-1-3 10:24<a class="zz" href="home.php?mod=space&uid=54876">作者：update</a> 阅读<em id="_viewnum">(1001)</em> 评论: <a href="http://www.oecr.com/portal.php?mod=comment&id=7349&idtype=aid" title="查看全部评论"><em id="_commentnum">5</em></a></p> <div class="zxfb" ><a href="http://www.oecr.com/portal.php?mod=rss&catid=58" class="y xi2 rss" target="_blank" title="RSS">订阅</a></div> </div> <!--[diy=diysummarytop]--><div id="diysummarytop" class="area"></div><!--[/diy]--> <div class="s"> <div class="ss"><div><span>导读： </span>由澳大利亚研究人员团队领导的一项令人兴奋的新研究揭示了免疫系统如何将癌细胞保持在休眠状态。研究人员希望突破性的观点为研究免疫治疗技术提供新的途径，这种技术可以在无限期内基本上阻止肿瘤的生长。</div> </div> <!--[diy=diysummarybottom]--><div id="diysummarybottom" class="area"></div><!--[/diy]--> <div class="d"> <!--[diy=diycontenttop]--><div id="diycontenttop" class="area"></div><!--[/diy]--> <table cellpadding="0" cellspacing="0" class="vwtb"><tr><td id="article_content"><div> 由澳大利亚研究人员团队领导的一项令人兴奋的新研究揭示了免疫系统如何将癌细胞保持在休眠状态。研究人员希望突破性的观点为研究免疫治疗技术提供新的途径，这种技术可以在无限期内基本上阻止肿瘤的生长。</div><div><br></div><div><p style="text-align: center;"><a href="data/attachment/portal/201901/03/102421kf84ffao7lukfur1.jpg" target="_blank"><img src="data/attachment/portal/201901/03/102421kf84ffao7lukfur1.jpg"></a></p></div><div><br></div><div> 虽然许多现代癌症研究正在研究破坏这些致命细胞的方法，但一项新的研究已经研究了一种可能不同的方法来对抗这种令人讨厌的疾病。科学家长期以来一直认为，在某些情况下，恶性癌细胞可以长时间静止而不会扩散或引起与疾病相关的症状。这个过程被称为癌症免疫平衡，虽然已知它是由身体的免疫系统介导的，但我们并不确切知道它是如何起作用的。</div><div><br></div><div> “我们尚未理解的是负责控制肿瘤和处于休眠状态的机制，”新研究的作者之一Jason Waithman说。“我们所知道的只是存在癌症控制的“黑匣子” - 如果我们能够更好地理解这一过程，我们就有可能学会如何在更多患者中利用它，从而挽救更多生命。”</div><div><br></div><div> 这项新研究归巢于一种称为组织驻留记忆（TRM）T细胞的免疫细胞。TRM细胞在大约二十年前被鉴定出来，并且它们在功能上与其他类型的免疫细胞不同。为了研究TRM细胞对癌症免疫平衡的影响，我们开发了一种小鼠黑色素瘤模型以及一种新的成像技术，使科学家能够实时观察这些免疫细胞的运动。</div><div><br></div><div> “使用特殊的显微镜，我们可以看到个体黑色素细胞位于小鼠皮肤中，可以观察到T细胞穿过皮肤，找到黑色素细胞并控制这些细胞的生长，”为该研究开发新型成像技术的研究人员Simone Park解释道。研究人员称，下一步是观察当TRM细胞耗尽时黑素瘤细胞会发生什么。结果值得注意，在移除TRM细胞后触发肿瘤生长。研究人员得出结论，TRM细胞在抑制癌症进展和维持癌症免疫平衡方面发挥着重要作用。</div><div><br></div><div> 为了更好地理解这些TRM细胞如何使癌细胞保持休眠状态，研究人员称还需要进一步的工作。之前的研究发现，TRM细胞水平升高的癌症患者已经证明了更好的一般治疗结果。</div><div><br></div><div> “这项研究的下一步是深入研究这一机制，以便我们能够更频繁地进行这一过程，”Waithman表示。“我们希望这项研究将为我们提供新的方法，使我们能够将癌症维持在休眠状态，并有效地治愈人们。”</div><div><br></div><div> 这项新研究发表在《自然》杂志上。</div><div><br></div><div><p microsoft="" yahei",="" simsun;="" background-color:="" rgb(255,="" 255,="" 255);="" text-align:="" center;"="" 255);"="" style="text-align: center; word-wrap: normal; margin: 0px; padding: 0px; color: rgb(143, 143, 143); font-family: 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